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This classifier essentially learns the metabolites best differentiating between the classes.
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The indices were calibrated by determining which variable or variable combinations and aggregation method best differentiated between least- and most-disturbed sites.
Orthogonal partial least square discriminant analysis (OPLS-DA), a supervised multivariate regression technique, was performed to identify components that best differentiate between predefined classes of samples while dissecting orthogonal components which do not differentiate between these classes.
To further differentiate between the consistent solutions we choose to test our predictions for the mad1mad3 and mad2mad3 double deletions which best differentiated between the models.
An artificial neural network was used to search features to form diagnostic classifiers that can best differentiate between malignant and benign lesions.
Receiver-operating characteristic (ROC) curves were constructed to determine the cut-off values that best differentiated between having the disease or not [ 24].
The BCTQ was also the outcome measure which best differentiated between the group of patients who had improved and those unchanged or worse.
As shown in Fig. 2b, we identified 16 genes whose change in expression level best differentiated between the two groups (P < 0.01, individual t-test).
Examination of the acetylation type, as determined by genetic and chromatographic methods, demonstrated that the parameters that best differentiated between the three types of acetylation were AUC0 6, AUCtotal, and maximum concentration of INH (Cmax).
Backward stepwise procedures (p in = 0.05: p out = 0.10) were used to search for the models that best differentiated between participants with SA + NSSH, SA only, and NoSA history.
Further studies need to identify which combination of tests can best differentiate between patients and healthy subjects.We decided to videotape participants performing the tests to exclude all disruptive elements.
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