The best described function for Smn is in pre-mRNA splicing [ 8, 57].
The C2, PX and PH domains have been implicated in protein-protein interactions, but perhaps their best described function involves their ability to modulate membrane targeting of proteins.
The best described cellular function of XIAP is its role in limiting apoptosis through inhibition of apoptotic caspases (Gyrd-Hansen & Meier, 2010) and, as recently reported by us and others, its role in facilitating innate immune signalling downstream of the NOD1 and NOD2 bacterial sensors (Bauler et al, 2008; Damgaard et al, 2012; Krieg et al, 2009; Lipinski et al, 2012).
To determine whether survival or detection probabilities were best described as functions of factors such as tag size, river flow, release day, or average travel time, we considered several candidate models.
The scaling of brain metabolism, therefore, is best described as a function of the total number of neurons in the brain, regardless of how that relates to brain mass or neuronal density across species.
Inspired by Fitts' law, we studied four possible models and concluded that movement time for a distal pointing task is best described as a function of the angular amplitude of movement and the angular size of the target.
It is possible that the variation is best described as a function of the average intensities of both channels.
The Presenilin gene encodes an eight to nine-pass transmembrane protein best described to function as the catalytic subunit of the γ-secretase multiprotein complex after an endoproteolytic processing, but also as a regulator of calcium flux in the ER.
This pattern of preference is best described mathematically by a hyperbolic function (Green et al., 2004; Rachlin et al., 1991).
The best-described function of lncRNAs is the regulation of gene expression.
Although the best-described function of LPL is hydrolysis of triacylglycerol (triglyceride) and generation of fatty acids (Mead et al, 2002), PEX5 LPL and PEX5 LPLvar are missing the first three exons of LPL, and therefore, parts of the N-terminal domain of the wild-type protein that are essential for such catalytic function (Semenkovich et al, 1990; Ben-Zeev et al, 1994).
