Computational time is also taken into account through choosing the best form of conjugation coefficient as well as mesh size.
In general, ketone/aldehyde condensations are best suited for conjugation reactions in vitro or at the cell surface because the reaction requires an acidic pH and high concentrations of the labeling reagent, which are problematic in terms of cell toxicity [224].
As determined by five-fold cross-validation, the model that was trained using the combination of amino acid composition and evolutionary information performs best in identifying ubiquitin conjugation sites.
While the inter- and intra-molecular movements of mobile elements can obviously have major consequences for the organization and composition of the host genome, it is probably the mechanism of conjugation that best enables the dispersion of these elements throughout the gene pool.
In fact, as shown in this work, Eex_R388 inhibits conjugation more than 500-fold, much more that the best recipient mutation found.
As with the PEGylation of SCKs, it was found that conjugation of chelators for the PET-active radionuclides was best performed onto the polymer precursors to allow for efficient coupling and accurate quantification and characterization studies to be performed.
With 80% of mIgG3 heavy chains labeled after only 1 h of UV exposure, the L17BPA variant displayed the best cross-linking performance ever reported of any Protein Z or Protein G based conjugation technique.
While communicating with actual Spanish speakers is generally the best way to learn the language, for some skills (like verb agreement and conjugation), it can be useful to take a more formalized approach to studying so that you can get the foundational knowledge necessary to carry on an actual conversation.
Porphyrin is considered as one of the best candidates for various organic electronic devices, due to its molecular planarity and π-conjugation.
NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.
