Sentence examples for best characterized effector of from inspiring English sources

The best characterized effector of PI3K is the serine/threonine kinase Akt.

Putative plant peptide-hormone mimics are some of the best characterized effectors in PPN.

The mTORC1 complex must be intact for mTOR phosphorylation at S2448 (33) by p70S6 kinase (34), the best characterized downstream effector of the mTORC1 complex.

Rho-associated serine-threonine protein kinase (ROCK) [ 11, 12] is one of the best characterized downstream effectors of Rho.

The PAKs (p21-activated kinases) are among the best characterized downstream effectors of Rac and Cdc42.

Specifically, the raf family (a-raf, b-raf and c-raf) of proteins code for serine/threonine kinases, originally isolated as a viral oncogene contributing to cellular transformation and are one of the best characterized Ras effectors to activate the mitogen-activated protein kinase (MAPK) signaling pathway [14].

Rho-associated coiled-coil-containing protein kinase (ROCK) is one of the best characterized Rho effectors.

mTORC1 regulates, through phosphorylation, a number of downstream effector proteins, the best characterized of which are p70 ribosomal S6 protein kinase-1 (S6K1) and eukaryotic translation initiation factor-4E (eIF4E -binding proteIF4E -binding (Laplante and Sabatini, 2012).

We also characterized effector functions following re-stimulation with autoantigen.

RAS has been found to activate several other effector pathways, the two best characterized of which are the Raf/MAPK and PI3K/AKT pathways.

Goto-Kakizaki (GK) rat is one of the best characterized animal models of spontaneous T2DM.