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The best characterized effect of DRAM-1 is on autophagy and so we tested whether DRAM-3 is also an autophagy modulator.
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Caffeine has varied pharmacological effects, but one of its potent and best characterized effects is inhibition of adenosine receptors (AR).
The best-characterized effect of dopamine in the retina is in mediating the light-dependent uncoupling of horizontal and amacrine cell gap junctions [reviewed in ref. 28].
The best characterized functions of RND3 are its inhibitory effect on Rho kinase-mediated biological functions including actin cytoskeleton formation, phosphorylation of myosin light chain phosphatase, and apoptosis 6– 8. Two recent mouse studies revealed an indispensable role of RND3 in mouse neuron development 9, 10.
Another important mediator of cell homeostasis with cardio-protective effects is SIRT1, the largest and best characterized member of the Sirtuin family.
Their imposex response remains the best characterized example of endocrine disruption in wildlife, with adverse population-level effects in the low nanogram per liter range for a single chemical, TBT (Matthiessen and Gibbs 1998).
We are far from having a large enough list of alleles with known differing fitness effects, even for the best characterized of model organisms.
Using large cohorts as well as standardized therapy, husbandry and testing batteries, we show that DMF exerts beneficial effects in the two best characterized mouse models of HD.
Goto-Kakizaki (GK) rat is one of the best characterized animal models of spontaneous T2DM.
One of the best characterized downstream targets of ROCK2 is LIM domain kinase (LIMK).
Dismutase activity is the best characterized function of SOD1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com