Sentence examples for best characterised function of from inspiring English sources

The best characterised function of E-cadherin is homotypic, calcium-dependent cell cell adhesion; however, the observation that E-cadherin is also capable of interacting with the αEβ7 integrin to mediate leukocyte cell cell adhesion [Nature 372 (1994) 190] suggests that it also participates in heterotypic interactions.

The best characterised function of VHL is its role as a negative regulator of hypoxia-inducible factor (HIF), through oxygen-dependent degradation of the HIF- α subunit, of which there are two isoforms HIF-1 α and HIF-2 α (Maxwell et al, 1999).

The best characterised functions of miR-1 are related to the regulation of genes involved in muscle function [29]; in D. melanogaster it is required for post-mitotic growth of larval muscle [30], targeting mRNAs that impair muscle development [28].

The uncoupling proteins (UCPs) are a family of mitochondrial proteins whose best-characterised function (in the presence of suitable activators) is to cause partial uncoupling of oxidative phosphorylation by dissipating the protonmotive force generated by the electron transport chain.

The VHL tumour suppressor gene product (pVHL) has multiple functions (see Frew & Krek 2007 references within) but its best-characterised function is the ability to regulate proteasomal degradation of hypoxia-inducible factor (HIF -1α and HIF -1α(Mandell et al. 1999), and overexpression of HIF-2α in a RCC cell line counteracts pVHL tuMaxwellppretsor altivity (Kondo et al. 2003).

The best-characterised role of Ago2 is the processing of microRNAs to mediate degradation of target mRNAs.

To date, the best characterised LATS1/2 function is the regulation of YAP/TAZ by phosphorylation, thereby playing a crucial role in mammalian cancer and stem cell biology.

Sequence similarity searches were carried out for several of the best characterised members of this functional group with good sequence coverage in our data set.

Classically, cells with high levels of Notch activity suppress the differentiation of their neighbours [ 4], and in some mammalian tissues activation of Notch is associated with tumours, the best characterised example being gain-of-function Notch1 mutations in human T cell acute lymphoblastic leukaemia/lymphoma [ 32].

The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes.

One of the best characterised transcription factors of the hTERT gene is c- myc (Wang et al, 1998; Greenberg et al, 1999; Kyo et al, 2000; Xu et al, 2001).