Sentence examples for best binding sites from inspiring English sources

For each of the predicted target sequences, the PWM supplied by MacIsaac et al. was used to predict the best binding sites, plus any additional binding sites with a log-odds of greater than 3.0.

From a law of mass action perspective, keeping gene-specific transcription factor abundance low, i.e., spanning the Kd values of the best binding sites, could prevent them from binding to lower affinity sites, with an undesired transcriptional effect [ 46].

Identifying the best binding site, they say, should speed up cancer vaccine development, lead to new diagnostic tests that detect the first appearance of cancer cells, well before tumors develop, and sort out disorders that are difficult to diagnose, such as Lyme disease.

EE can be useful for converting the K d predicted for binding to the single best binding site into the overall binding, allowing for pose flexibility.

By comparing calculated proton chemical shifts of the ligand to experimental data, it was possible to determine the best binding site pose.

The best binding site for the Myf transcription factor was motif a5 with a score of 1.21 and p-value of 1.0 × 10-3.

That is, we are looking for the single best binding site on either strand of each sequence explained either by the gapped or ungapped PWM.

When the two best conserved binding sites (137C and 137D) were simultaneously mutated, reporter expression was 32% (p = 0.0001) compared to expression from the mutated vector alone, suggesting that sites C and D play a major role in the response to miR-137.

OLIGOs were designed using the MFOLD software (Genetics Computer Group, Madison), which provides the best RNA binding sites, and also takes into account the possibility of secondary structure folding that may facilitate or impede binding to sequences.

Yet, for log-odds PWMs, negative elements do not contribute to the scores of highly scoring TFBS and thus may be different without affecting the sets of the best recognized binding sites.

There are several cases where VHELIBS can prove very helpful: VHELIBS can be used to choose structures to use for a protein-ligand docking: with VHELIBS, the user can choose the structures with the best-modeled binding sites.