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In each case, we have used the best available methodologies for detecting the cells and further studies on a larger cohort of patients along with improvements in assays, for example, CellSearch applied to bone marrow aspirates, may improve the correlation between CTCs and DTCs.
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While we used the best available methodology for calibration, our calibration corrections remain dependant on population assumptions.
Many consider the measurement of the change in the minimal JSW of standardized knee radiographs to be the best available methodology for evaluating the anatomical progression of OA [ 3, 32- 34].
Consider a parameter investigated by the best available methodology found in 80% of the subjects of a cohort and in 20% of a perfectly matched control group [think of, e.g. the dexamethason suppression test (DST) or with a corticotrophin-releasing hormone infusion (Dex-CRH)] of melancholic/ major depression (Carroll et al. 1981; Holsboer 2000).
The goal of this study is to produce an updated version of the carnivore supertree that accounts for both current taxonomic opinion and additional data sources (primarily DNA sequence data, but also additional phenotypic data) as well as corrects for the shortcomings present in the original analysis by using the best available methodology and analytical methods.
Each referral center from Albania, Algeria, Bosnia Herzegovina, Croatia, Egypt, France, Greece, Italy - Messina and Naples - Malta, Montenegro, Morocco, Slovenia, Spain, Tunisia and Turkey provided a list of 50 unselected consecutive CD cases diagnosed in the center by the best locally available methodologies.
A template based on the best available consensus methodology is preferable to a list of variables created without formal methodology.
We believe that our data and methodologies are the best available to the industry.
Our results imply that the proposed methodology is the best available to deal with small samples of blood pressure measurements.
To obtain the best available evidence, relevant studies were scored on scientific methodology and the LoE they provide.
Unfortunately, no general methodology still enables to choose the best available technologies from the many potential solutions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com