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The skeletal abnormalities of C/EBPβ−/− mice were much milder than those of the p57−/− mice which were perinatally lethal due to various defects analogous to Beckwith-Weidemann syndrome in children, including cleft palate and body wall dysplasia besides severe dwarfism [38], [45] [47].
Besides severe changes of systemic and renal haemodynamics, the infusion of contrast media has negative effects on renal tubular cells.
Besides severe mandibuloacral dysplasia with clavicle and rib hypoplasia, and delayed bone age, our patients showed typical features of progeria, such as alopecia, loss of eyebrows and eyelashes, bird-like nose, coarse and senile appearance.
Besides severe forms of male infertility, which is referred to as azoospermia, reduced fertility may also have unexplained reasons and this is termed as subfertility or idiopathic infertility [ 3].
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YAP overexpression results in ductal metaplasia in the pancreas besides causing severe abnormalities in the colon, skin, and liver[64, 65].
Interestingly, having any warning signs at first presentation is also a risk factor for death among ICU cases (Table 5), besides for severe dengue [ 25].
'Barbera' shows high sensitivity to FDp infection: besides showing severe symptoms at the beginning of the vegetative season (early syndrome), infected plants clearly show typical symptoms of the disease in summer, which can frequently result in whole plants turning purple.
However, both LRB and HDR isolation systems still lack a self-braking mechanism, under severe earthquakes, besides the aptitude for low-mass structures.
Keep in mind that this difficult process took almost two years, in which I suffered permanent dizziness, vertigo and severe headaches, besides the sleep problems.
In the brain, alteration of sphingolipid metabolism is believed to be essential for neuronal function as evidenced in a number of severe disorders besides AD including Niemann Pick disease, amyotrophic lateral sclerosis, Parkinson and AIDS dementia [ 24].
Recently, two studies in children of Papua New Guinea showed that certain common infections, and especially B19V-infection can play a critical role in the etiology of severe anemia besides other factors, such as malnutrition and iron deficiency, in a highly endemic area for malaria [ 21, 40].
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