Although other factors besides promoter activity often have a role in protein expression levels, studies have shown that activity of the Cox-2 promoter correlates well with protein expression [13].
Interestingly, besides promoter methylation of PI3 kinase pathway-associated forkhead box (FOX) genes, we identified promoter methylation of three other FOX transcription factors: FOXA1, FOXC1, and FOXF1.
Note that besides promoter regions, additional homologous sequences of interest (e.g. intronic regions) could be added to the input dataset.
However, we could not detect promoter methylation in KTA2 cell; so it is also suggested that there might be other mechanisms besides promoter methylation for the downregulation of HBB expression in anaplastic thyroid cancer.
Secondly, we detected reproducible transcriptional activity (in biological replicates); besides, sigma promoter motifs were identified for some of these ncRNAs.
Genetic studies have shown that, besides the promoter region, internal regions of VRN-A1 such as intron 1 are also involved in the diffe rential regulation observed between spring and winter wheat [ 28].
To test if hfq transcription in F. novicida originated from other promoters besides the single one identified 65 bp upstream of the F. holarctica hfq gene [13], RT-PCR was performed using reverse primer FN-hfq-151R and forward primers FN_miaA-25F, FN_miaA-274F, and FN_miaA-833F (designated lines a, b, and c respectively) internal to miaA (Fig. 1A).
However, even the "demarcater", who explicitly took exception to health promotion, may to some extent operate as a health promoter (besides preventing disease), but without using the terminology.
Genome-wide analysis has thus helped define a growing geography of biologically significant methylation patterns besides that associated with CGIs near promoters.
The Straits Times, a newspaper in Singapore, reported that no reason had been given by the local promoter besides "unforeseen circumstances and difficulties".
