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Clinical reports indicate that Akt is significantly over-expressed in prostate tumors compared to benign prostatic tissue, and its level is directly correlated with tumor progression and prostate-specific antigen (PSA) serum levels, as well as a higher Gleason score [ 23, 26].
To study the specific role of various subunits of PP2A, we have compared the differential expression pattern of PP2A-A α/ β, -B′ γ, and -C in benign prostatic tissue and malignant PCa tissue spots on a prostate TMA and in the clinically relevant PCa cell model system PC-3 and LNCaP cells, to explore the mechanism in both the AD and the AI status of PCa.
To compare the uptake of 18F-MK-9470 in locally confined PCa, benign prostatic tissue and muscle by means of the AUC values of each time interval, the paired one-way ANOVA and Bonferroni post hoc testing were used.
We utilized a tissue-microarray (TMA) containing specimens from benign prostatic tissue and malignant tumors from 448 patients who underwent radical prostatectomy for localized prostate cancer.
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The staining intensity of MIC-1 protein in prostate adenocarcinoma samples was scored and compared with normal and adjacent benign prostatic tissues, and the value was considered enhanced if the staining intensity was higher by one or more points.
Thus, from the results of the present study and the sparse literature on that topic, it seems that CD57 is expressed in a high proportion of benign prostatic tissue, PIN, and early, low-grade PCa.
Quantitation of E-cadherin in the membrane portion of the epithelium resulted in a significant decrease in expression in all PCa samples compared to benign prostatic tissue, while HGPIN and BPH samples showed no significant differences in expression.
For immunohistochemistry paraffin sections of tissue microarrays comprising prostate cancer and corresponding benign prostatic tissue samples were treated with xylene and ethanol.
This hypothesis was supported by our results from TMA studies of primary prostate cancer and benign prostatic tissue from 448 patients.
New PCa-specific microbubbles are under development for exact detection and differentiation of PCa and benign prostatic tissue.
We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue.
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