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The characteristics of the patients with benign prostatic disease and prostate cancer are shown in Table 1 > -wrap-foot>.
The relationship between circulating concentrations of interleukin-6 and C-reactive protein in patients with benign prostatic disease and prostate cancer is shown in Figure 1.
The correlation coefficients for patients with benign prostatic disease and prostate cancer were rs=0.632, P<0.001 and rs=0.663, P<0.001, respectively.
As the distribution of interleukin-6 and C-reactive protein concentrations was skewed, they were logarithmically transformed to illustrate their relationship in patients with benign prostatic disease and prostate cancer.
White et al. [ 35] used a glycomic approach to characterize glycans cleaved from prostate-specific antigen and prostatic acid phosphatase purified from seminal samples representative of normal controls, benign prostatic disease, and prostate cancer patients.
Histological sections of 12 paraffin wax-embedded prostate cancers and 12 non-malignant prostate tissues from specimens of benign prostatic disease without malignancy were obtained from Department of Pathology, University of Liverpool, UK.
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Subjects with other malignancies, hormonal disorders or benign prostatic diseases and men with the prostate specific antigen >= 4 ng/ml were excluded from the control group.
However, considering different categories of controls, we observed that PSA and UCF-DNA integrity had the same low specificity in benign prostatic diseases (39%), confirming that the PSA test has a high number of false positive results [ 3], especially when benign conditions such as prostatitis or adenomas are present.
Approximately 50% of patients with advanced prostate cancer have elevated levels of serum IL-6 in comparison with men with normal prostates, benign prostatic hyperplasia, prostatitis and localised disease (Twillie et al, 1995; Drachenberg et al, 1999).
The expression of TGF-β1 is elevated in most carcinomas and many proliferative diseases including benign prostatic hyperplasia, prostate cancer and prostatitis [9], [10], [11], [12].
With informed consent prostatic tissue was obtained from males undergoing treatment for malignant (CaP) or non-malignant benign prostatic hyperplasia (BPH) disease.
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