Sentence examples similar to benign prediction from inspiring English sources
The use of frequency information in the model allows for confident benign predictions for this type of polymorphism.
This seems too benign a prediction.
These two mutations (CFH p.His1165Tyr/ MCP pAla353Val) have a benign phenotype prediction (Polyphen-2), and MCP pAla353Val has polymorphic prevalence (1000 Genomes Project).
Here, we identified a total of 14 polymorphic nucleotide sites (Supplementary Fig S2); these were not further considered as disease-causing because of a benign pathogenicity prediction.
The patient was found to have two genetic variants, one located in the CFH gene and one in the MCP gene, reported by the Polyphen-2 database to have a benign phenotype prediction.
PolyPhen and PolyPhen-2 produce predictions (benign, possibly damaging, probably damaging) based on the rules regarding the SNPs effect on protein functional sites, the protein structure and the presence of the same peptide substitution in homologous sequences.
If there is no difference between wt and mut, then the prediction is "benign," else the prediction is "unknown".
The mutations were a homozygous missense mutation with prediction of benign and tolerated by PolyPhen-2 and SIFT, respectively, and a homozygous premature termination mutation in RP1L1.
The PSAAP classifier agreed with PolyPhen in 13 benign and 22 pathogenic predictions for 76% agreement (35 out of 46).
Our algorithm agreed with SIFT in 19 benign and 16 pathogenic predictions for 76% agreement (35 out of 46).
