Sentence examples for benign phenotype with from inspiring English sources

These effects were accompanied by changes in Wnt/β-catenin signaling, and gene expression analysis suggested that surviving tumour cells had been routed to a more benign phenotype with reduced Wnt signalling and increased aerobic glycolysis.

Although the BACE1-deficient animal model presented a relatively benign phenotype with high viability, suggesting that the possibility of targeting β-secretase would be a safe therapeutic approach, further testing indicated that the drastic inhibition would result in hypomyelination and behavioral abnormalities such as seizures [ 27– 30].

Three, individuals II:2, III:1 and III:2 (see Fig.  1), in the original study [ 11] had a 'particularly benign phenotype with very mild distal leg weakness and hypotrophy…' Of these three one has since died, but the other two (III:1 and III:2) were available for re-review.

Individuals with familial renal glycosuria, a condition caused by genetic mutations in SGLT2, have been characterized as having largely benign phenotypes with normal life expectancies and no long-term renal deterioration or known health consequences (17, 18).

Malignant cells can be converted to a benign phenotype accompanying with reduced tumour cell proliferation and increased apoptosis (Spira and Carducci, 2003).

A variant that strengthened the natural site and showed normal or increased levels of the wild-type isoform, consistent with it having a benign phenotype and/or polymorphic; d.

A benign phenotype for 249A>G (m.896A>G) would not be in disagreement with HIA data and could be explained structurally.

Tumors from rats fed the olive oil diet were characterized by a more benign phenotype, while those from rats on corn diet were found to be more aggressive.

Despite the patient's benign phenotype, pathologic changes were evident at the molecular level.

Patients not only have classic IPEX syndrome but, unexpectedly, may have a more benign phenotype.

Due to the benign phenotype of Dmd mdx, it is difficult to monitor clinical benefits from any therapeutic trial.