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Apparently, A1611G did not interfere with the fixation of C788T in the control line, but did interfere in the benign line.
In the midpoint population of control line 1, only C788T was detected, while in the midpoint population of benign line 1 there were four genotypes, including C788T.
If CI were responsible for this outcome, then in the benign line, both mutations should be adaptive and A1611G should have a significant advantage over C788T.
By the endpoints, C788T was present in all genotypes of control line 1 but was not detected in benign line 1, and A1611G was detected in all genotypes in the endpoint populations of both treatments.
Indeed, both mutations had a significant selective advantage over their ancestor (Fig. 2; benign – A1611G: t4 = 11.7, P = 0.0003; C788T: t4 = 7.4, P = 0.0017), and the A1611G mutation had a significant selective advantage over the C788T mutation (t4 = 6.3, P = 0.0032), supporting that C788T was lost due to CI by A1611G in the benign line.
Similar(55)
Marshall is expert at singing painful lines as if she can't feel a thing, and at crying out seemingly benign lines as if she's being lanced.
Instead, they reproduced a carefully tended official narrative with either celebratory accounts of empire, or equally pernicious, by turning their collective heads away from the violence that underwrote Britain's imperial past and towards more benign lines of inquiry.
(One of the track's more benign lines, "How you take my '09 jail tweet and run?," accused Minaj of stealing one of Remy's signature vaunts—"all these bitches is my sons"—from her Twitter timeline while she was incarcerated).
In nonhuman studies, Oates and colleagues [ 44] have shown that increasing the expression of OPN is sufficient to produce a metastatic phenotype in a previously benign cell line (rat mammary tumor line).
Double-stranded cDNAs of both tester and driver were synthesised from 2 μg poly(A)+-containing RNA derived from the cultured benign cell line, Huma 123 and the malignant cell line MCF-7.
At protein level, three human malignant cell lines produced more VEGF (2.7 7.9 ng ml−1) than the benign cell line (1.3 ng ml−1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com