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BLT2 was significantly upregulated in malignant IPMNs when compared with benign IPMNs and normal pancreatic specimens.
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We computed the same summaries for the difference between early neoplastic tissue and normal tissue - specifically breast ductal carcinoma in situ (DCIS) and normal breast tissue, colon tubular adenoma and colon normal, intraductal papillary mucinous neoplasms (IPMNs) and normal pancreas, and follicular thyroid adenomas, and normal thyroid tissue.
Typically, breast cancers are known to be stiffer than benign lesions and normal breast tissue [25].
This might be explained by the fact that complete tumour specimens and not microdissected IPMNs were subjected to quantitative RT PCR and benign IPMNs are often smaller than malignant IPMNs.
There have also been meta-analyses on these tools for differentiating malignant and benign IPMNs.
Prostate cancer cells exhibited a pronounced global decrease in methylation compared with benign and normal tissue.
The cancer cases were consecutive; the benign and normal cases were randomly selected.
These tissues contain a variety of pancreatic tumors as well as benign and normal pancreatic tissues.
We reviewed recent studies and summarized the mural nodule size of benign IPMNs in Table 1.
Cytology based on endoscopic retrograde cholangiopancreatography was reported to have a high specificity (97.2%) but a poor sensitivity (35.1%) for distinguishing benign IPMNs from malignant IPMNs [17].
- In the differential diagnosis between pancreatic carcinoma and mass-forming pancreatitis, morphological, ductal, functional information as well as DWI with IVIM analysis are becoming important tools to achieve a correct diagnosis [ 8]. - DWI also useful improves diagnostic accuracy for differentiating malignant from benign IPMNs of the pancreas [ 9].
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