However, this trial was not powered for cardiovascular endpoints, the inclusion of calcium supplementation may have counteracted the benefits of vitamin D, and vitamin D dose may have been too small [ 57].
In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health.
We must also consider the possibility that apart from direct cellular benefits of vitamin D on cancer that vitamin D deficiency has indirect effects which are hard to quantify but may have a significant impact on cancer outcomes.
Though the chemoprotective role of vitamin D has been speculated, the exact benefits of vitamin D supplementation in preventing and reducing cancer risk still need to be clinically proven.
Tanning bed proponents cite the health benefits of vitamin D to support indoor tanning, including concerns that reduced vitamin D levels or certain vitamin D receptor polymorphisms may be associated with increased incidence of various cancers, including melanoma.
We would welcome new prospective randomised studies on the health benefits of vitamin D supplement in populations at risk of vitamin D deficiency.
- As recommended in the K/DOQI guidelines improvement in vitamin D status can result to non-calcemic benefits of vitamin D by the autocrine production of 1,25(OH)2D3.
50 Overall, results of the content analysis demonstrate that the print news media often frame vitamin D and supplementation in terms of the health benefits of vitamin D for everything.
As awareness of the benefits of vitamin D spreads, more and more companies are adding vitamin D to foods that otherwise would not be good sources.
Health benefits of vitamin D can be fully dissociated from the UV exposure risks with oral vitamin D supplementation or from adding vitamin D-rich foods to the diet, although optimal levels remain to be established.
We considered that the risks for skin cancer may outweigh the benefits of vitamin D synthesis, for the doses of UV radiation required to achieve and maintain vitamin D sufficiency in older adults.
