Because of the high impact of PIAS2 on the dynamic behavior of this pathway, the knockout of this gene in ESCs may facilitate differentiation of ESCs, while increased PIAS2 production may enhance the self-renewal of ESCs or benefit induction of a differentiated cell to the pluripotent state.
Thus, while some properties of GCs may be of benefit, induction of resistance in tumour cells towards cancer therapy may be dangerous for patients.
The benefits of induction therapy, including a decreased incidence and delayed onset of acute rejection, must be balanced against the considerable cost and side effects of the individual agents, including risk of infection.
The benefits of induction chemotherapy have been widely investigated since the 1980s.
Robust evidence on the risks and benefits of induction of labour is needed to guide decisions about pregnancy management.
Moreover, we will evaluate whether the relative benefits of induction of labour will be stronger in multiparous women and in women with a ripe cervix at baseline.
Moreover, we will evaluate whether the relative benefits of induction of labour will be stronger in women with a ripe cervix at baseline and in women with a short cervical length at transvaginal sonography.
None the less, this is the first study that we are aware of that has quantified the benefits of induction of labour in terms of a reduction in perinatal mortality.
Clinical decision-making requires consideration of the potential risks and benefits of induction of labour against expectant management with delivery at term or when complications such as chorioamnionitis intervene necessitating delivery.
Early identification of patients who are unlikely to benefit from induction therapy is important as they could be saved from unnecessary side effects of ineffective treatment and potentially avoid further delay of surgical resection.
