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Understanding the mechanisms by which EGFR inhibition modulates repair of DNA damage will inform design of optimal combinations for future studies and is critical to maximise benefits in the clinical setting.
Our classifier is also expected to bring benefits in the clinical setting for personalized management of glioma patients.
We have previously shown that, amongst inflammatory cytokines, IL-6 in particular is significantly elevated in C33Y TRAPS patients [ 27], and that the anti-IL6 receptor therapeutic antibody tocilizumab can have benefits in the clinical management of TRAPS [ 28].
The findings of the feasibility study provides evidence that COMPASS may have tangible benefits in the clinical setting for supporting patient-specific eligibility selection for thrombolysis in the treatment of acute ischaemic stroke and personalised risk communication, including support for recording of decision-making.
Robust experimental pipelines, improved HTS technology and application of the latest advances in machine learning will all be required, but such combinations are likely to provide new insights into the function of the adaptive immune system, and ultimately translational benefits in the clinical context.
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Speed of spoligotyping could be a benefit in the clinical setting.
The apparent benefit in the clinical cure rate observed in traditional meta-analyses does not persist after TSA.
In the present study, the tumour vaccine-treated group also indicated significant benefit in the clinical objective responses based on the assessment of traditional RECIST criteria.
However, the apparent benefit in the clinical cure rate observed by traditional meta-analysis does not persist after trial sequential analysis.
To defend the statement that colloids are superior, one must prove their benefit in the clinical setting described: paediatric septic shock.
In summary, for both CsA and RIC large multi-centred randomised controlled clinical trials are required to confirm their cardioprotective benefit in the clinical setting and investigate whether these interventions impact on clinical outcomes for patient benefit.
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