Though there was evidence of benefit in a number of secondary analyses, particularly in the apolipoprotein E ε4 negative subgroup, the primary cognitive efficacy analysis was negative.
The addition of Androgen Deprivation Therapy (ADT) to radiation therapy for locally advanced prostate cancer has demonstrated an improvement in local control and overall survival benefit in a number of randomized controlled trials [ 1- 6].
It has been found that the percentage of local control after 5 years following a treatment regimen consisting solely of radiotherapy is improved by adding chemotherapy (5-FU, cisplatin etc)., which has conferred survival benefit in a number of trials.
administration of mRNA encoding different tumor antigens together with GM-CSF resulted in both CD4+ and CD8+ responses against multiple antigens and moreover induced clinical benefit in a number of patients.
Ischaemia-driven revascularisation has been shown to be of benefit in a number of trials, most recently in the FAME study in which an invasive method of measuring the flow reserve of the microcirculation (Fractional Flow Reserve, FFR) was used to allocate patients to intervention or observation versus a clinical decision on intervention based on angiography alone.
Bevacizumab, a humanised murine monoclonal antibody to VEGF, has resulted in clinical benefit in a number of tumour types, including colorectal, non-small-cell lung and breast cancer, and is currently being evaluated in CRPC in a randomised double-blinded, placebo-controlled phase III study administering docetaxel with or without bevacizumab (CALGB 90401).
Apple is the only company that uses a proprietary charging port, which benefits it in a number of ways: If people buy accessories like docks, clock radios and chargers made just for Apple products, they have to keep buying Apple products if they want to keep using their gear.
Scatter-hoarding also benefits plants in a number of ways, such as transporting seeds away from the parent plants and increasing the probability of reaching a site more suitable for germination.
