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CONCLUSION: These results suggest that patients with chronic or recurrent, treatment-resistant depression may show long-term benefit when treated with VNS.
BACKGROUND: In 1995, the Bypass Angioplasty Revascularization Investigation (BARI) found that patients with diabetes had a survival benefit when treated with surgical revascularization versus balloon angioplasty, prompting a National Heart Lung and Blood Institute (NHLBI) "Clinical Alert". The influence of the BARI findings and of the Clinical Alert on practice patterns is unknown.
Patients with KPS ⩾70 may benefit when treated with lapatinib in addition to trastuzumab after completion of local therapy.
In post hoc analysis, patients with an initial APACHE II score in excess of 25 had a survival benefit when treated with APC.
Currently, patients with node positive or metastatic colon cancer demonstrate an overall survival benefit when treated with a fluoropyrimidine-based regimen.
All four individuals had at least some positive benefit when treated with pyridostigmine, with one individual regaining ambulation after starting medication.
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Arthritic mice benefited when treated with the FAAH inhibitor JNJ1661010.
Patients with far lateral extraforaminal disc herniation may also benefit when treated by microscopic tubular discectomy, since wide midlines approaches with muscle retraction is prevented [ 9, 14].
Gabapentin has shown some benefit when treating aggressive behavior in patients with dementia, but it has not been well studied (Hawkins et al 2000; Kozman et al 2006).
However, patients with methylated MGMT benefited significantly when treated with TMZ alone rather than radiotherapy, whereas patients with an unmethylated MGMT gene promoter treated with TMZ alone fared worse [6], [8].
This dichotomy has important potential implications for human disease and has preliminary support from available clinical studies of TNF inhibitors in humans, in which patients with advanced CHF have shown no benefit or worsened when treated with anti-TNF-α therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com