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Significant benefit was found when treating Streptococcus pneumoniae and "species other than Haemophilus influenzae", though statistical significance was also not achieved with Neisseria meningitides infection.
However, no increased benefit was found when using hyperfractionated or accelerated fractionation [conventional fraction of 1.8 or 2.0 Gy per day] in this meta-analysis.
Data from observational studies indicated that statins lowered the risk of HCC in various patient populations; however, no clear benefit was found when only rigorously conducted RCTs were included in the analysis [ 101 ▪].
When continuous measures were pooled a moderate to large advantage for ketamine was reported early in the ECT treatment course [ 26], but no benefit was found when end-of-treatment response and remission were meta-analysed [ 37].
While no overall benefit was found when we directly compared patients receiving combination versus monotherapy, we observed a dichotomous effect when patients were stratified by their risk of death.
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For early-stage residual disease (rT1-2), a significant benefit is found when salvage treatment is performed.
Interestingly, dialysate [Na] varies widely across the countries of the Dialysis Outcomes and Practice Patterns Study (DOPPS); moreover, no survival benefits were found when using a lower dialysate [Na].
For example, in a recent abstract from an academic institution in the same province, no statistically significant benefit to an internist-based hospitalist program was found when compared to Clinical Teaching Units staffed by academic general internists [ 20].
However marginal benefits can be found when compared the results obtained for laminates filled by 3% and 6% of nanoclays.
However, the trial was terminated when no survival benefit was found.
Although more data are needed, these findings are consistent with the recent meta-analysis of data from 357 older adults, in which enhanced benefits of exercise training were found when combined with creatine supplementation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com