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Tight glucose control [TGC] and corticosteroids are examples of nonproprietary and recombinant Activated protein C [rt-APC] an example of proprietary intervention with reversal of effect between publications, from benefit to harm.
A ratio of benefit to harm above the line could justify our current situation.
Have you considered the available alternatives and compared them in terms of a benefit to harm ratio?
The overall balance of benefit to harm in terms of mortality was in favour of screening.
Targeting screening to men at higher polygenic risk could improve the benefit to harm balance of screening.
Conclusions This analysis supports regulatory decisions that dabigatran offers a positive benefit to harm ratio when compared with warfarin.
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The treatment plan needs to balance the potential benefits to harm of antidepressant administration (El-Mallakh and Hollifield, 2008) and benzodiazepines (Brunette et al., 2003) administration.
If the net favourable balance of health benefits to harm is only to be found among the more mature population, should this be reflected in age-specific drinking guidelines?
We investigated the ratios of benefit to harms when extrapolating from high-risk to average-risk subjects.
Otherwise, some investigators may be tempted to estimate the ratio of benefit to harms in the trial of high-risk subjects and extrapolate the ratio to average risk subjects.
Using high risk subjects instead of average-risk subjects from the general population may lower statistical power, increase costs, and yield a misleading ratio of benefit to harms than actually the case.
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CEO of Professional Science Editing for Scientists @ prosciediting.com