A treatment benefit (ie, superiority to placebo) in terms of clinical-symptoms score, maintenance of pulmonary function, and some inflammatory reaction was demonstrated, and the treatment was well-tolerated and caused no resistance problems.
Additionally, efficacy outcomes for a number of new agents (such as paclitaxel, oxaliplatin and capecitabine) have not shown definitive clinical benefit or superiority to older drugs in patients with advanced GC [ 5- 7]; and in some patients therapy results in severe, unpredictable toxicity without any tumor response.
This technique would enable patients in underprivileged societies to benefit from the superiority of interlocked intramedullary nails.
Both studies were stopped at the first preplanned interim analysis for benefit and demonstrated superiority of RD compared with single-agent dexamethasone in terms of response rates, time to progression, and overall survival (OS).
Benefiting from the superiority of hydrophilic GO-PDA skin layer and interconnected porous PEN nanofibrous supporting layer, the resultant optimized PEN/GO-PDA nanofibrous composite membrane exhibited an excellent permeate flux of 99.7 L/m2 h (0.1 MPa, pH = 3.0) and a high rejection (99.8%) for Direct Blue 14 with the concentration of 100 mg/L at 25 °C.
People in a position of information superiority can benefit from the market by communicating reliable information to the party with an information disadvantage.
The proposed FLECH market shows its superiority to benefit DER owners and facilitate DSO dispatch and operation, which will contribute to improve the stability and reliability of distribution grid even transmission grid.
Using a two-sided, two-sample t test and a sequential test-wise significance level of 0.05, with a minimum of 89 patients in each albiglutide group, the albiglutide vs placebo comparison had at least 91% power to reject the null hypothesis of no treatment benefit if albiglutide treatment superiority was ≥0.5% and the SD for HbA1c change from baseline was ≤1.0%.
Although the technology used has been shown to be ready for clinical practice [ 16], and can be used as one parameter in combination with current clinical parameters, these signatures need to be prospectively validated to prove their superiority and benefit above and beyond the use of standard clinico-pathological prognosis variables to guide the choice of adjuvant therapy.
Nevertheless, and although the use of Rb has been already described in a number of reports in the literature, the merit of the present study is that it encourages us to benefit from the substantial superiority of the PET technique for instance over SPECT, resulting in good image quality even in obese patients.
The PO25 study was the largest of these randomized trials in the first-line setting and demonstrated extremely strong clinical benefits, evidenced by significant superiority in TTP and ORR, with letrozole compared with tamoxifen as first-line hormone therapy.
