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The confirmatory cohort comparison was based on the MCER, where individual cost effectiveness of a patients' care process was defined by means of a (sub) process cost/patient benefit relation ≤ 100 €/% WOMAC increase.
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Our method of choice for mutagenesis was UV radiation due its good cost-benefit relation.
The results show that the approach has an excellent cost-benefit relation, classifying more than 90%% of microalgae in a well distributed way, overcoming the supervised algorithm SVM.
The analysis of three experiments showed that innovative technical and regulation measures can lead to benefits such as the reduction of fishing effort, the improvement of the cost-benefit relation and the reduction of the direct impact on the seabed and the indirect effect on the ecosystems through reduce discards and the emission of CO2 into the atmosphere.
Although the application of ITS in the past decades shows an impressive positive cost-benefit relation, it became more and more recognized that a shift from a technique-oriented approach to a result-oriented approach of ITS was needed to cope with the increasing traffic problems.
It is, therefore, necessary to study these effects to assess efficiently the cost-to-benefit relation.
More prospective research is needed to assess the cost-benefit relation of our approach.
Furthermore, these programs show a remarkably positive cost-benefit relation [ 12], which is of interest in Switzerland and other industrialised countries suffering from exorbitant health costs.
The integration of health systems should improve the system performance, so that the efforts are justified to the extent that they lead to more accessible and higher quality services with a better cost-benefit relation, and users satisfaction [ 10].
Future prospective studies will have to be conducted with more patients and over an even longer period of time, evaluating the validity of our approach and our preliminary results in an independent patient sample on the one hand and the cost-benefit relation on the other hand.
If the efficacy of this therapy is demonstrated in this RCT, Snow Control will be integrated into the basic services for cocaine users, and we will potentially be able to reach "hidden" cocaine consumer groups in the general population [ 11] in a remarkably positive cost-benefit relation [ 12].
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