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Only fluoxetine appeared to offer a moderately significant benefit profile (OR = 2.39).
The favorable risk:benefit profile demonstrated in some studies of adult patients may be translated to the pediatric setting. .
The favorable risk:benefit profile demonstrated in some studies of adult patients may be translated to the pediatric setting.
Despite the relatively small sample size, our study suggests that olanzapine has a superior risk:benefit profile compared to risperidone.
Under such circumstances, it may be justifiable to generalize the favorable risk:benefit profile demonstrated in adult patients to the pediatric setting.
Based on the composite endpoint data, CDA has an unacceptable risk:benefit profile versus AL for the treatment of malaria in G6PD-deficient patients.
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Therefore, in these patients, treatment skews the risk-benefit profile toward toxicity without benefit.
Relative net risks arise when the risks of a research intervention are justified by its potential clinical benefits, but the intervention's risk-benefit profile is less favorable than the risk-benefit profile of one or more available alternatives.
Indirect net risks arise when a research intervention has a favorable risk-benefit profile, but the intervention diminishes the risk-benefit profile of other interventions provided as part of or in parallel to the study.
Analysis of the ethics of clinical research thus requires evaluation of three related risk-benefit profiles: (a) the risk-benefit profile of the potential new interventions(s) under study; (b) the risk-benefit profile of the included research procedures; and (c) the risk-benefit profile of the study as a whole.
In conclusion, contraceptive counseling in migraine should take into account the risk-benefit profile of the individual woman before prescribing CHCs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com