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Despite evidence of household and community-based TB transmission – including MDR and XDR TB, little is currently known about air exchange and transmission risk in household or community settings and the potential benefit of ventilation [ 2].
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21 23 However, there is little evidence regarding the benefits of ventilation with low VTs in patients undergoing surgery without ARDS preoperatively.
Despite recent randomized controlled trials (RCTs), the benefit of current ventilation strategies designed to limit iatrogenic lung injury remains controversial.
The technique has the additional benefit of maintained ventilation and airway protection.
These results do not preclude a benefit of this ventilation mode in special patients or circumstances [ 37].
However, several randomized clinical trials have failed to show any significant clinical benefit of a ventilation strategy applying higher positive end-expiratory pressure (PEEP) and low tidal volume.
This situation has fueled the search for adjuvant pharmacological strategies to advance the benefit of protective ventilation in an additive or synergistic manner.
Although the main benefit of mechanical ventilation is to improve gas exchange [ 12], it can in fact open the way to pulmonary infection, sepsis and muscle atrophy, prolonging weaning after lung transplant and making it difficult [ 11, 42, 43].
Although trends in radon related health burdens may be helped if effective action is taken to reduce smoking prevalence over coming decades, the relative benefit of reduced ventilation on carbon dioxide equivalent emissions is likely to decline over time with progressive decarbonisation of household energy supplies.
There was no benefit in duration of ventilation, ICU length of stay or 28 day mortality amongst 99 patients randomized to receive 200 mg hydrocortisone continuous infusion per day for 2 days compared with placebo after an intubation dose of etomidate [ 44].
However, the benefits of noninvasive ventilation in immunocompetent patients with acute respiratory failure are debated.
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