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As novel molecular-targeted therapies are introduced, whose primary action is to slow the growth of tumors, it will be important to ensure that the clinical trial design will effectively capture any clinical benefit of these agents.
We reviewed the results of preliminary studies of select novel agents for metastatic prostate cancer and discuss the potential benefit of these agents for earlier stage disease, eg biochemically recurrent prostate cancer with high risk features.
However, the benefit of these agents is confined to patients with EGFR mutation [ 7, 8].
Studies have been conducted to assess the benefit of these agents as therapy for ILD.
There is a 2 3 mmHg drop in blood pressure with TZDs, a further potential benefit of these agents.
Taking all these factors and, especially, real-world clinical observation into consideration, we contend that the overall benefit of these agents remains limited for most patients.
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Therefore, the clinical benefits of these agents in treating oral candidiasis remain to be established [ 1].
Some controversy exists regarding whether the putative benefits of these agents outweigh their expense.
Benefits of these agents include convenience, elimination of risks from indwelling central venous catheters and a different toxic profile.
Despite the benefits of these agents, tumour cells become refractory to treatment and resistance will eventually develop in the majority of patients.
Our data show that DEX potentiates the antiangiogenic activity of docetaxel, suggesting a putative mechanism for the palliative and survival benefits of these agents in metastatic CaP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com