As a result, many recommended the alternative term "gene transfer" to more accurately represent the purpose and benefit of the intervention.
After removing some of the trials and data based on more rigorous standards for a high quality meta-analysis, a significant benefit of the intervention could no longer be shown.
The benefit of the intervention was observed also using different analytical approaches.
What would be the cost and benefit of the intervention for society?
Results can be analyzed at the point where the maximal benefit of the intervention is hypothesized to occur.
Further investigation is needed to understand why women with income above US$75,000 did not show the same benefit of the intervention.
The clinical measures to evaluate the disease-modifying effect of an intervention are readily confounded by any symptomatic benefit of the intervention.
Relevant adverse effects may partly or fully counterbalance the benefit of the intervention, may be considered especially important by patients, or be associated with serious morbidity, higher mortality, or significant impact on quality of life.
The researchers also noted that for both shows combined, 40% of the recommendations mentioned a specific benefit of the intervention being touted.
Then, as prevalence gradually declines among women, the circumcised men also start to receive an indirect benefit of the intervention.
The authors' comments typically emphasized the benefit of the intervention but only 10% described limitations of the research.
