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This strategy is to ensure that the maximal benefit of the agent will be investigated.
The substantial decrease in numbers of participants makes it difficult to evaluate the durability of benefit of the agent.
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The end-users, on the other hand, can utilize the benefits of the agent technology in the most convenient manner.
This work also demonstrates some of the benefits of the agent based schemes in providing flexibility, adaptability, software reusability, and maintainability.
This allows us to highlight the benefits of the agent's moral sensitivity to both the principal and the agent, and thereby, point out the potential cost of ignoring this moral sensitivity.
These factors include the nature and distribution of potential harm, the benefits of the agent or activity under suspicion, the availability of feasible alternatives, and the overall goals of public policy.
The generally accepted efficacy surrogate is a reduction in HbA1c that is commensurate with the baseline HbA1c of the patient population studied (greater improvements of glycemic control expected if higher baseline hyperglycemia), taking into account the concomitant health issues within that population and additional benefits of the agent (12).
We agree with Wise and colleagues that studies assessing the effects of mechanical cleaning prior to chlorhexidine application are needed to better define the benefit of this agent in reducing the incidence of nosocomial pneumonia in the intensive care unit.
Patients on enzalutamide had improved outcomes in terms of overall survival, radiographic PFS, and time to PSA progression compared to individuals on placebo regardless of their steroid use, further confirming the benefit of this agent.
These studies unfortunately do not address the essential need for mechanical cleaning prior to chlorhexidine use and therefore potentially underestimate the benefit of this agent in reducing ventilator-associated pneumonia.
Considering the demonstrated antipruritic efficacy of TriCalm hydrogel, additional studies to further investigate the clinical benefit of this agent in pruritic conditions would be valuable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com