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Placebo-controlled phase III trials of carboplatin/paclitaxel [ 40] and gemcitabine/cisplatin [ 41, 42] alone or with sorafenib have demonstrated no additional benefit of response rate, PFS, or OS.
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The proportion of responses elicited by Aδ-fibers increases with the initial temperature T0 and decreases for the benefit of responses elicited by C-fibers when this temperature falls.
When there is considerable phenotypic plasticity underlying trait expression, individual response patterns ('norms of reaction') themselves can adaptively evolve as the benefit of responses for some habitats are lost (Scheiner 1993, 2002, and references therein).
Modifications were made on perceived barriers and perceived benefits of response items.
The benefits of response fall into two categories: for individuals who are nonadherent or unable to maintain diet restriction and medical food intake, sapropterin may lower blood PHE without further diet modification; and for individuals who maintain blood PHE within the therapeutic range by dietary adherence, sapropterin may allow liberalization of dietary PHE and less medical food intake.
As well, the response time of the MAP3/NO-based sensors worsened with implantation time analogous to control sensors, suggesting that the benefit of reduced response time is only attained when sensors are still releasing NO.
Under natural conditions the benefit of this response is obvious as it enables tadpoles to metamorphose before pools dry out [22].
The results in the current study may be explained by the MFC in each hemisphere being biased towards encoding the future benefit of a response to the contralateral side of space.
Physicians need to discuss both the benefits (likelihood of response and improved patient-reported functional outcomes) and the risks (AEs) with patients for shared decision-making.
It might remind us that the parameters beyond SUV and %ID/g could be of benefit to response evaluation.
We don't get the benefit of internal responses to Jonathan's memo, but comments on the blog post suggest concern that Sun sales is not necessarily aligned with Jonathan's goals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com