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We assessed the efficacy of continuation treatment with antidepressants in a meta-analysis of relapse prevention studies in the five principal anxiety disorders, to explore the benefit of continuation treatment in each disorder, and their relative efficacy across these disorders.
We found evidence for the benefit of continuation of chemotherapy beyond progression only for men who had isolated worsening of pain.
A survival benefit of continuation of beta-blocker therapy in patients with ADHF was demonstrated by Butler et al. [ 20] and recently confirmed by Fonarow et al. [ 21], Jondeau et al. [ 22] and Orso et al. [ 23].
In high-risk patients (those with femoral neck T-scores 2.5 T-scores 2.5 bisphorphonates for 3–5 years, the benefit of continuation from the aloweronate 'Fosamax Long-Term Extension' trial seems to far outweigh the risks.
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In such settings, benefits of continuation of TMP-SMX may still outweigh the risks associated with earlier discontinuation of TMP-SMX after programs of antiretroviral therapy is increasingly implemented in these regions.
Even though the present study design did not expressly provide for any follow-up and no data are therefore available to substantiate the authors' claim, they do have good reasons to believe that with regard to a number of former study subjects the obvious benefits of continuation proved a persuasive enough argument.
Nonetheless, investors' valuation of sustainability around the world has evolved over time, involving diminishing reactions to U.S. firms and increasing benefits, particularly of continuation on the index, over time.
The benefits of using continuation are clearly demonstrated for both codes for a large class of problems.
Yet, despite these limitations, the overall results provide further evidence to support the benefits of donepezil continuation, and of memantine treatment despite discontinuation of donepezil.
Although it is not clear why patients would continue to benefit from continuation of trastuzumab in the setting of disease progression, it is possible that HER2 inhibition may continue to provide synergy with different chemotherapeutic agents administered sequentially.
Subjects in the two double-blind studies were eligible for the open-label study if they had completed at least 24 days of previous double-blind treatment or discontinued because of tolerability issues, if they were expected to benefit from continuation of treatment, and if they had no other serious, unstable illnesses and were otherwise physically healthy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com