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Despite some long-term benefit obtained in a small fraction of patients with this combined treatment, the median overall survival remains poor, at 14 months only (Stupp et al, 2005).
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Because of this limitation, it is debatable whether benefits obtained in a simulated representation of a complex situation can be realized in clinical practice.
Clinical trials should not be considered if the benefit obtained in experimental studies is limited or weak.
Nevertheless, the four NSABP adjuvant studies showed decreased death risk with adjuvant treatment, similar to the benefit obtained in stage C [37].
For patients with grade III tumours qualitatively it was in the same direction as the benefit obtained in patients with grade I and II tumours.
The effectiveness, efficacy, safety, and tolerability of these drugs in patients with CCC have been based on these small studies and its use is extrapolated due to the benefit obtained in HF from other causes.
4. Apply the fitted model (2) to the original data set to obtain the predicted probability of a prostate cancer diagnosis, and then compute the net benefit at various threshold probabilities. 5. Compute the difference in the net benefit obtained in (3) and (4) for each threshold probability.
The difference between the expected net benefit obtained using perfect information and the expected net benefit obtained in the presence of uncertainty (that is, the maximum expected net benefit obtained with less than perfect information) is known as the expected value of perfect information (EVPI).
Using this approach we used data from the Monte Carlo simulations to calculate the NCB j for each j individual simulation trial using the equation (5) N C B j = ρ Δ B j - Δ R j where Δ R j is the incremental risk and Δ B j is the incremental benefit obtained in the j individual simulation trial.
To minimise these effects, we will convert costs and benefits obtained in different years to a base year: the year with the most recently published price levels.
The evidence of benefits obtained in this study show that GAGs are neither a specific drug nor an alternative to actual therapies for RA, but they represent a small step in our understanding of this complex pathology.
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