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From the 36 patients, 9 had progressive disease and 27 obtained a clinical benefit (objective response or disease stabilization).
Appropriate endpoints for the palliative setting are clinical benefit (objective response plus disease stabilisation rate), OS and toxicity, with symptomatic benefit rather harder to establish.
127 While authors suggest that 50% of patients experienced a clinical benefit, objective responses were experienced in only 3 patients (11.5%).
Patients having a clinical benefit (objective response or stable disease at 3 months) on DTIC therapy had lower BRAF and NRAS expression levels compared to patients progressing on therapy (p = 0.037 and 0.003, respectively).
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The framework was advantageous in reflecting the conflicting equity and benefit objectives for water allocation, maintaining the water balance of watershed, and dealing with system uncertainties.
Choosing the parcels of the maximum-score alternative of the "ecological benefits" scenario (objective d) generated an equal benefit for erosion protection but lower benefits for structural enrichment.
"Any government that has a sincere desire for reform and progress should understand the benefit of objective and constructive criticism," he said.
This would eventually benefit the objective function, and it would not violate any constraint.
Tropical greenwall practice, hindered by inadequate scientific knowledge and experience, can benefit from objective assessment of species performance and growth deficiency.
With regard to patient benefit, these objective measures may have several limitations.
In oncology, the term 'clinical benefit' means objective response or disease stability in the absence of limiting toxicity [ 20 ].
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