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Because of the high impact of PIAS2 on the dynamic behavior of this pathway, the knockout of this gene in ESCs may facilitate differentiation of ESCs, while increased PIAS2 production may enhance the self-renewal of ESCs or benefit induction of a differentiated cell to the pluripotent state.
Thus, while some properties of GCs may be of benefit, induction of resistance in tumour cells towards cancer therapy may be dangerous for patients.
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Despite the clinical benefits, induction and maintenance therapy using anti-TNF-α drugs is expensive.
This study was designed to elucidate the benefit of induction chemotherapy followed by CRT combined with capecitabine, with or without erlotinib during induction chemotherapy and a CRT phase.
Early identification of patients who are unlikely to benefit from induction therapy is important as they could be saved from unnecessary side effects of ineffective treatment and potentially avoid further delay of surgical resection.
The question on the potential benefit of induction chemotherapy preceding a concomitant CT-RT remains unanswered.
The benefit of induction chemotherapy in locally advanced oral squamous cell carcinoma (OSCC) remains to be clearly defined.
5– 8 Most of the benefit of induction chemotherapy is restricted to more locally advanced, stage II III patients.
Correlative studies from the aforementioned randomized trials could assist in identifying candidate biomarkers predictive of benefit from induction treatment.
In a meta-analysis, Pignon found no significant benefit from induction chemotherapy as opposed to concomitant chemotherapy in head and neck cancer [ 5].
Randomised phase III trials comparing the standard sequential approach (using cisplatin and 5-FU) to concomitant chemo-radiation (using cisplatin) are required to provide a definite answers to the questions regarding the benefit of induction chemotherapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com