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In terms of future action however, even though overall the mean DIF for each major was negligible enough that DTF was not found, future administrations of this test could certainly benefit from some modification of items; particularly item 5 and possibly the additional 7 items that were highlighted by two of the tests employed in the analysis.
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In view of future long-term home use, there were indications from some patients that the existing DiAs GUI could benefit from some modifications, e.g., easier reading of the display and clearer feedback when a bolus is being delivered.
Although the work is definitely of eLife quality, the manuscript would benefit from some modifications, further experiments and reorganization, as detailed below: Major comments: 1) We are not sure if the microarray/ChIP-Seq analysis adds much to the paper.
Future CAR T cell therapies could benefit from combined modification of endogenous TCR genes, histocompatibility genes, and components of signalling pathways.
But skeptics note that not all investors in a given mortgage pool would benefit from a modification even if the pool as a whole is made healthier, since investors with first rights to homeowners' monthly payments are better insulated from defaults than those at the back of the line.
When trimming against RVSs, LUCY2 and cross_match did not seem to benefit from this modification as much as SeqClean did.
Our findings support the notion that patients without evidence of tumour hypoxia do not receive benefit from hypoxia modification.
Therefore, we performed a retrospective study to explore whether expression of combinations of necrosis, HIF-1 α, CAIX and GLUT1 predict benefit from hypoxia modification.
Our previous work showed that tumour necrosis is an attractive and easily assessable factor that may be used to predict benefit from hypoxia modification in bladder cancer (Eustace et al, 2013a).
In support, we showed previously that tumour necrosis is an independent prognostic factor in invasive bladder cancer, and both necrosis and expression of the hypoxia-inducible enzyme carbonic anhydrase IX (CAIX) predicted benefit from hypoxia modification (Eustace et al, 2013a).
This information allowed us to investigate whether there are factors that control the recalcitrance of both grasses and legumes, which could help in identifying fractions of the plants that would most benefit from genetic modification or targeted growth.
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