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A new functional imaging probe that selectively targets PDAC with high sensitivity is a critical unmet need in PET/CT or PET/MRI that could transform patient management by allowing earlier PDAC detection and surgical intervention and that could improve preoperative staging of disease to decrease the number of unwarranted surgeries in patients who might benefit from experimental systemic therapy.
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Docking simulations are however far from infallible and benefit from experimental verification, as false positives and negatives are common.
The work is rather modest in scope and would greatly benefit from experimental validation of the tRF targets.
However, the likelihood of benefiting from experimental treatment was similar between different PS groups.
These high-risk patients might benefit from additional systemic treatment [ 7].
Therefore, luminal B tumors may benefit from additional systemic therapy [ 12- 14].
It is tempting to speculate that patients might benefit from additional systemic effects under these conditions.
These are the patients which could benefit from a systemic drug approach and/or require specific clinical and instrumental followup.
As patients that are DTC positive after NACT have an unfavorable outcome, they might benefit from additional systemic treatment.
However, some retrospective studies reported a 10-y RFS of 81%86%% and suggested benefit from adjuvant systemic therapy.
Comparisons with published experimental systemic concentrations are made for molecules ranging from small lipophilic substances, such as ibuprofen, to polypeptides, such as calcitonin, and proteins, such as insulin.
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CEO of Professional Science Editing for Scientists @ prosciediting.com