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Our analyses showed that 70% of patients from this cohort would specifically benefit from dose adjustments in drugs that are mainly used in cardiology and psychiatry, followed by infectious diseases (54%), neurology (42%), gastroenterology (30%), transplant (25%), pain (9%), and oncology (8%).
In this paradigm, patients with subtherapeutic IFX concentrations who lack ATI may benefit from dose intensification.
Long-term follow-up of this small pilot study is compatible with a benefit from dose escalation, but confirmation from larger trials is required.
It identifies those patients who will benefit from dose escalation versus those who are unlikely to respond to this strategy (high titers of anti-drug antibodies) [ 33].
This would enable both appropriate use of the kinase inhibitor and identification of patients who will benefit from dose escalation or combination therapies.
The available data suggest that prostate cancer especially in patients with intermediate risk profile benefit from dose escalation (reviewed in [ 20]).
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The MITO-7 findings are consistent with the conclusion of another European trial by van der Burg et al. [35], which confirmed no evidence of benefit from dose-dense paclitaxel and carboplatin over a standard tri-weekly regimen.
Levendag et al. [ 22] reported that some patients with stage T2b NPC lesions may benefit from dose-escalation by brachytherapy boost when the tumor had regressed to the clinical target volume after EBRT pretreatment.
Only a subpopulation of patients (with a methylated O 6 -methylguanine-DNA methyltransferase (MGMT) gene prO 6 -methylguanine-DNAO 6 -methylguanine-DNAmethyltransferaseent with added loMGMTine in terms of overall survival, at the cost of increased toxicity [ 4].
In conclusion, late-preterm infants are at significant risk for RSVH through at least 6 months of age and would benefit from dosing throughout the RSV season.
As praziquantel dosing schemes such as the current one will generally only include owned dogs, stray dogs will not benefit from dosing, and dosing compliance may be lower for unwanted dogs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com