As new therapeutic possibilities emerge, it is becoming increasingly important to identify individual patients who are unlikely to respond satisfactorily and who may benefit from carefully selected agents [ 1].
In addition, the realistic range of values for sensitivity may have been perceived as narrow, and participants may not have seen much benefit from selecting an option with 92% sensitivity over one with 86% sensitivity (the largest gain possible) compared with previous studies that have used wider ranges.
Using these biomarkers, we were able to predict the patients most likely to benefit from selected multiagent chemotherapy with a high degree of accuracy.
The fact that some individuals with HS might have a contribution of MH-type pathophysiology might also explain why there has been anecdotal evidence suggesting a possible benefit from dantrolene in selected cases.
In addition, in the initial generations of selection, the breeding programs could benefit from mutually selecting sires and dams from each other when the genetic correlation was as low as 0.40 to 0.60.
Recent mathematical models of mate choice suggest that in most environments, females can reliably derive substantial fitness advantages from attending to current condition, but may gain little, if any, further benefit from simultaneously selecting mates on the basis of past immune function [21], [22].
Provided that the antenna geometry allows it, the new algorithm can also benefit from a new procedure that selects the angular distribution of the received signal from a set of possible candidates.
Selection in composite breeds can also benefit from selecting the taurine allele at some sites and the indicine allele at others to capture the 'best of the two subspecies'.
If larger females are more fecund and aphid symbionts significantly affect adult lady beetle size, then females might benefit from selecting aphids with symbionts, despite their negative survival effects.
As such, Phylogenetic profiling-based approaches can benefit from flexibility in selecting and weighting of reference genomes as demonstrated here.
