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An exception is the HEAL Study, which observed a benefit for even very modest levels of physical activity.
When all individuals are highly risk averse (α= 0.05), social distancing leads to a positive benefit for even the most highly infectious diseases, see Figure 8.
The main determinant of whether toxic or expensive treatment is worthwhile is the absolute risk reduction that it produces, and it is perfectly proper to use the fact that patients who already have a very good prognosis anyway and are at low absolute risk cannot have a large absolute benefit (for, even if a small risk is halved the absolute benefit is small).
Our close proximity to Portland, OR is also a benefit for even more choices. .
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AdSense and AdWords would never have been invented had Larry and Sergey not understood the value of providing a monetization platform for others to benefit from, even for users not on Google.
He has played benefit after benefit for charity, even when he himself was busted, or nearly so.
Shiffrin claims that we have serious qualms about harming someone without their consent to secure a pure benefit for them, even when we can be sure that they would regard the pure benefit as far outweighing the harm (see also Steinbock and McClamrock 1994).
Avoidance of unnecessary use of anti-D has therefore been suggested as a 'soft benefit' for NIPD even though anti-D continues to be judged safe for routine antenatal use by NICE [ 1, 6].
In general, providing people with simple and reliable ways of influencing behavior is an important benefit for them, even with no current evidence that the impact is long lasting.
More recently the CLOCC trial, a randomised trial of ablation and chemotherapy vs chemotherapy alone, showed a survival benefit for ablation, even though the trial recruited extremely badly and had to be concluded as a randomised phase-II trial (Ruers et al, 2008).
These patients, as well, are likely to agree to participate in just about any type of research in the hope that it will provide some degree of benefit for them, even if they are told this is not likely to be the case.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com