Next, we divided the cohort in patients with clinical benefit and no clinical benefit, defined as described in Methods section.
"Big Tax Break Often Bypasses Idea of Charity" (front page, April 25) weighs public benefit, defined as payouts to charity, against tax deductions for gifts of closely held stock to a "supporting organization".
A sustained benefit (defined as continuous improvement of at least 50%) was obtained in 3 patients who were followed-up for 69, 77 and 107 days (Fig. 3).
Clinical benefit (defined as PR rate plus SD rate) occurred in 45 patients (55%).
The primary end point of the study was clinical benefit defined as the rate of CR+PR+SD⩾6 months duration.
Patients randomised to sunitinib had longer clinical benefit, defined as Q-TWiST scores, than patients randomised to IFN- α.
The primary end point was clinical benefit, defined as best radiologic response [including complete response (CR), partial response (PR), or stable disease (SD)] achieved during the study period.
The primary end point of the study was clinical benefit, defined as the sum of complete responses (CR), partial responses (PR) and >24 weeks stable disease (SD).
In each of these cases, the patient experienced radiographic response (defined as a reduction in size and/or increase in calcification), clinical benefit (defined as a reduction in pain and/or improvement in function or mobility), or both.
The combination of docetaxel and adecatumumab in a Phase IB trial achieved a clinical benefit, defined as a complete or partial response or stable disease, in 44% of patients with relapsed or refractory advanced-stage breast cancer [ 69].
