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The restrictive RBCT strategy was not associated with harm or benefit compared to liberal strategy.
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As a conclusion, restrictive RBCT strategies were associated with neither benefit nor harm compared to liberal strategies, and RBCT did not impact mortality but the occurrence of nosocomial infection.
We confirmed benefit compared to placebo.
Conservative religions have the highest retention rates compared to liberal religions and nonbelievers.
A more restrictive fluid regimen (median 1640 ml) seemed to be beneficial in immediate postoperative pulmonary function compared to liberal fluid administration (median 5050 ml).
In 1999, the TRICC trial was published, and this study showed that a restrictive transfusion approach had similar outcomes compared to liberal transfusion strategy[ 3].
We proposed that conservatives, compared to liberals, have greater negativity bias [ 13], which includes both disgusting and threatening conditions in our study.
A number of randomised trials and subsequent meta-analyses in various surgical settings have shown that GDFT confers clinical benefits such as decreased postoperative morbidity and decreased hospital length of stay as compared to traditional, liberal fluid therapy [ 8- 14].
Compared to a liberal strategy of fluid administration, a conservative strategy including fluid removal prompted extubation in ARDS patients [7].
Notably there was a significant reduction in certain acute complications in the restrictive when compared to the liberal transfusion strategy group.
Trials of GDFT show clinical benefits over traditional liberal fluid administration, but fail to demonstrate benefits when compared to a restrictive strategy within an optimized enhanced recovery protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com