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This benefit can only be demonstrated in randomised prospective trials, which are ongoing in the metastatic setting.
The magnitude of benefit can only be determined precisely via large randomised-controlled trials with long-term follow-up.
Increased patient benefit can only be achieved by earlier clinical decisions, based on the results which require better integration of pre- and post-analytical phases (ultimately point of care testing).
In treating DMD, significant long-term benefit can only be conferred by dystrophin restitution, and of all the novel experimental therapies to treat DMD discussed here, only gentamicin administration and oligomer-induced exon skipping have resulted in readily detectable dystrophin expression in DMD patient's muscle.
It might even be the case that the full therapeutic benefit can only be achieved in a setting that does not attempt to isolate any part of the effect, and hence trials designed to estimate the specific component of a treatment effect will fail to evaluate the full therapeutic benefit.
From a manufacturing perspective, it would be ideal to introduce more stringent regulations to ensure that a health benefit can only be marketed following the completion and publication of clinical studies to define optimal dose and assure no potential adverse effects or drug interactions.
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Existing retiree health benefits can only be reduced with the agreement of the union.
But the extent to which American workers will share in those benefits can only be guessed at today.
These health benefits can only be obtained and preserved when physical activity is maintained over a long period of time.
However, its potential benefits can only be fully realized if teachers are properly trained to utilize such tools.
First, we will modify negative gearing rules so that the current generous tax benefits can only be claimed for new properties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com