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Intriguingly, this tool also gives a validated prediction as to whether the individual patient who receives adjuvant endocrine treatment tamoxifen will have an additional benefit by the addition of chemotherapy.
These findings may have clinical relevance, particularly after recent results suggesting a benefit by the addition of the anti-VEGF monoclonal antibody, bevacizumab, to chemotherapy for advanced ovarian cancer (Burger and Brady, 2010; Markman, 2011).
Several authors [ 4, 7, 10, 11, 13, 15] found a benefit by the addition of laparoscopic guidance, while the others [ 3, 6, 8, 16] showed they were equivalent in complications and catheter survival.
Combining bevacizumab with IFL chemotherapy regimens has demonstrated clinical improvement in overall survival (OS) or progression-free survival (PFS) in CRC (Hurwitz et al, 2004); however, subsequent studies using next-generation chemotherapy regimens such as FOLFOX, while maintaining a PFS benefit, failed to show an OS benefit by the addition of bevacizumab (Saltz et al, 2008).
Yeast breads, while they can be made without salt, often benefit by the addition of a small amount.
Drier products such as bananas or avocados, or even oranges that might be on the dry side, will benefit by the addition of liquids.
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It is recommended that model fermentation systems used in the experimenting of dietary effects on intestinal biomass composition be streamlined to only include necessary system design complexities, as the measured performance is not benefited by the addition of microbial immobilization mechanisms or semi-continuous emptying scheme.
The efficacy results were similar in both etanercept groups, indicating that patients inadequately responding to sulfasalazine would benefit by either the addition of etanercept to their existing (sulfasalazine) treatment or by switching from sulfasalazine to etanercept.
V3 is a planned multicenter, randomized trial whose objective is to evaluate the clinical benefit conferred by the addition of a second LV lead in nonresponders after at least 6 months of standard biventricular stimulation.
This study has therefore shown that the benefit conferred by the addition of cetuximab to standard chemotherapy for this disease is independent of tumor EGFR copy number.
Although this study adopted a high-dose regimen of capecitabine (830 mg/m oral twice daily from day 1 to day 21 every 4 weeks), there was no survival benefit conferred by the addition of capecitabine to the gemcitabine backbone (CapGem arm, 7.1 months vs. gemcitabine arm, 6.2 months; P = 0.08).
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