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Response to aggressive therapy was found to differ by subtype, with the greatest benefit being observed in the classical subtype and no benefit in the proneural subtype.
This was on the basis of a 5% benefit being observed in patients with Dukes C disease (35% of those with colon cancer in Australia), but assumed no benefit in patients with Dukes B disease (Dube et al, 1997; International Multicentre Pooled Analysis of Colon Cancer Trials IMPACTT B2) Investigators, 1999).
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A threshold effect was observed, whereby no additional benefit was observed for intakes of ⩾9 g per day.
Reduced benefit was observed for shorter treatment length and self-help administered in groups.
However, a considerable net environmental benefit was observed through an on-site sorting system.
By contrast, no therapeutic benefit was observed in TNBS-induced colitis.
To date, the initial results have been mixed: some studies showed benefit, whereas in others, no benefit was observed.
More recently in a clinical trial in triple-negative breast cancer, no benefit was observed for carboplatin in subjects with tumor-associated BRCA1 methylation, compared with BRCA1/2 mutation29.
However, this benefit was observed only for neutral pictures; and it was completely absent for the emotional pictures.
Surprisingly, no further benefit was observed after six or nine months of training, maybe due to the attention task we used (a "cue-flanker" test).
As a result of the experimentation with the use of such handy methods in the architectural design studio, a limited benefit was observed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com