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NeoCT is usually regarded as no benefit at first glance.
Neither the BIG1-98 trial or the ATAC trial showed any significant overall survival benefit at first analysis.
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Getting hitched does have financial benefits at first.
Although these two benefits at first sight may be considered logically equivalent, psychological research on framing suggests that this is not necessarily the case.
Roadside assistance can be another benefit which, at first glance, may be tempting, until exclusions for a home start or recovery service are applied.
The results show that, on average, treatment effects are underestimated in arms which do not show sufficient benefit at the first interim analysis.
The results show that the maximum sample sizes of the two-stage designs shown in Table 2 are higher than the corresponding fixed sample sizes, however, their expected sample sizes are much lower as they allow recruitment to be stopped early if the experimental treatment does not show sufficient benefit at the first stage.
The benefits of investing in immune defence have received far less attention than the costs, probably because these benefits seem, at first hand, to be obvious.
Even seceding half-heartedly, it seems, can have benefits.If at first you don't secede...The longest-running secessionist micronation is the Hutt River Province Principality in Western Australia.
This strategy showed its benefits when at first the tumor center was replaced by a core of starving dying cells -including many of the chemoresistant cells- and then had its exterior rim pulverized by chemotherapy: the repetition of this treatment eventually led to a tumor with no chemoresistant population and thus potentially curable.
The level of urban infrastructure economic benefit is evaluated at first.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com