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In virtual screening using homology models still conferred significant enrichment compared to random selection, with a clear benefit also observed in using models optimized through induced fit docking.
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Importantly, these benefits also observed in the 'non-achiever' subgroup of the protocol group, suggesting that hyper-resuscitation prior to insult improves outcomes even if it does not increase the measured oxygen delivery.
Updated results with longer follow-up demonstrated that the 5-year benefit in DFS with tamoxifen persisted through at least 10 years of follow-up, and a statistically significant survival benefit was also observed [ 6].
A treatment benefit was also observed for progression-free survival, 6-min walk distance and dyspnoea.
This mismatch between need and benefit is also observed in the second poorest quintile.
The survival benefit was also observed when only liver-related deaths were treated as 'events'events
This combination benefit was also observed in vivo using an MDA-MB-231 xenograft model and the mechanism underlying the combined effects we observed was further elucidated.
A lack of additional clinical benefit was also observed in a phase I/II study with soft tissue sarcoma patients [ 63].
A survival benefit was also observed with custirsen plus docetaxel (median survival 23.8 months; 95% CI, 16.2 months-not reached) compared with docetaxel only (median survival 16.9 months; 95% CI, 12.8 25.8 months).
This survival benefit was also observed in a recent prospective study in a medical intensive care unit (ICU) population that required ICU treatment for more than three days [ 10].
Preliminary studies by Chung et al. demonstrated that mice genetically deficient in FasL showed better survival after CLP than their wild-type counterparts (34 ), and a survival benefit was also observed when mice were treated with siRNA to block intracellular synthesis of Fas (28 ).
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