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This single and early administration of vasopressin has been criticized because, according to animal studies, vasopressin appears to be more beneficial in conditions of severe acidosis and, therefore, at a later phase of resuscitation [ 28].
However, NF- κB may also act beneficial in conditions of ischemic preconditioning, which was shown to protect against a subsequent prolonged ischemic insult through transcriptional activation of NF- κB.
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We propose that therapeutic modulation of SGK1 may be beneficial in conditions associated with muscle atrophy or degeneration.
Beyond the beneficial effect of the antimalarial in conditions of well-established disease, early HCQ use has been also associated with delayed SLE onset in humans [ 18].
The role of this enzyme in preventing intestinal inflammation has been demonstrated in zebrafish [ 66] and there is evidence of the beneficial effect of its administration in conditions of severe intestinal epithelial damage [ 67, 68].
NO availability regulates the role of VEGF-A on the vasculature: beneficial when NO is present and deleterious in conditions of reduced NO availability.
Consequently, GIK therapy in conditions of CABG may result in hypolipidemia that can potentially limit the beneficial effects of this therapy.
Our study design does not let us comment any further on whether corticosteroid injection is beneficial in this condition, but consideration of the risks and benefits of injection should be considered in the individual case; however, no reliable proof exists of the deleterious effects of peritendinous injections.
In particular, those plants that reduce the formation of NO may be beneficial in pathophysiological conditions where excessive production of NO is a contributory factor.
On the contrary, MDSC-mediated suppression of T-cell responses can be beneficial in pathologic conditions characterized by the unopposed activation of the adaptive immune system such as organ transplant rejection or autoimmune diseases [ 12].
Furthermore, the use of antioxidants [ 83] might be beneficial in patients with conditions of increased oxidative stress before HBOT is contemplated, especially since antioxidant supplementation is generally recognized as safe.
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