They speculated that chronically increased insulin secretion resulting from long-term nateglinide treatment could counteract the initial beneficial effects of reduced glucose excursion.
There is evidence that improvement in postprandial glycemic excursions may be beneficial, as elevated postprandial glucose levels have been suggested as an independent risk factor for many diabetes-related complications, including macrovascular disease (15– 15).
Siegelaar et al. performed reanalysis of the data of the HEART2D, which shows that targeting post-prandial glucose decreased intraday glycemic excursion would not be beneficial in reducing adverse cardiovascular events in AMI patients [ 28].
Vildagliptin decreased HbA1c levels in patients with poorly controlled type 2 diabetes with high doses of insulin, 62 and vildagliptin has also been reported to be beneficial for decreasing post-meal glucagon excursion in insulinopenic patients with type 1 diabetes; this effect was not secondary to a change in endogenous insulin secretion.
Further studies are needed to determine if pharmacologic therapy aimed at controlling glucose excursion in AMI would be beneficial in prognosis of this high-risk patient population.
The Yellowstone trip was more beneficial to Arthur's health than his Florida excursion, and he returned to Washington refreshed after two months of travel.
Ford's Excursion is a good example.
The excursion did Cosimo good.
Moreover slows gastric emptying –reducing postprandial glycemic excursions–, reduces body weight, systolic blood pressure and has beneficial effects in the cardiovascular and central nervous systems.
Overall, the addition of exenatide is beneficial with greatest potential in those who are overweight or with prandial glucose excursions not responding to oral therapy or insulin.
Other known beneficial effects of GLP-1 include slowing gastric emptying (which reduces excessive postprandial glucose excursions), suppression of glucagon (a counter-regulatory hormone), an increase in pancreatic islet β-cell mass, suppression of appetite and induction of satiety [ 8- 12].
