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The results showed that edge loading was predicted during normal walking, ascending and descending stairs activities under steep cup inclination conditions (≥55°) while no edge loading was observed during standing up, sitting down and knee bending activities.
Direct association of CIN85 to phosphatidic acid (Zhang et al, 2009) in concert with the membrane binding and bending activities of known CIN85 binding partners (Havrylov et al, 2010) could link SLP65 to signalling-competent membrane microdomains.
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Rox1 contains a high-mobility group (HMG) domain that is responsible for DNA bending activity [ 29].
These are occupations with a high likelihood of knee bending activity [ 20, 21].
Membrane bending was dependent on the specific interaction with LC3B as the LIR mutant showed strongly reduced membrane bending activity.
► The FAPP2-PH domain targets the protein to the trans-Golgi network and has membrane bending activity.
It is possible that Dichaete activity at HOT regions is mediated by this bending activity, helping to bring together complexes of other regulators.
As conformational changes in the DNA RepD complex are essential for nicking, it is possible that mutation of N189 might reduce bending activity.
We found that cross-linked p62 delta PB1 efficiently mediated membrane bending showing that the presence of ubiquitin per se is not essential for the membrane bending activity of p62.
Moreover, the α-helical structure appears to be a prerequisite for the binding and bending activity of the Pex11-Amph peptide, as insertion of prolines at key positions in the peptide prevented membrane deformation.
This indicates that, in addition to membrane binding, the membrane bending activity of Nup53 is conserved during evolution which suggests an important role for Nup53-induced membrane deformation in NPC formation and/or function.
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